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Carcinomas of the Ampulla of Vater are rare tumors, accounting for % of .. 17 . de Castro SM, van Heek NT, Kuhlmann KF, Busch OR. The complex histological structure of the papilla of Vater gives rise to a Neoptolemos JP, Talbot IC, Carr-Locke DL, Shaw DE, Cockleburgh R, Hall AW. The term ampullary tumor generally refers to either benign or malignant neoplasms that arise from the glandular epithelium of the ampulla of Vater, including 1.

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Predictors of failure after pancreaticoduodenectomy for ampullary carcinoma. Clinical significance of pathologic subtype in curatively resected ampulla of vater cancer.

Tumors of ampulla of Vater: A case series and review of chemotherapy options

Comparison with conventional sonography, computed tomography, and angiography. Vaterr et al[ 36 ] By using this site, you agree to the Terms of Use and Privacy Policy. Locally advanced and metastatic disease Surgery represents the main therapeutic approach for ampullary cancer, whilst unresectable tumors can be treated with either radiotherapy or chemotherapy. Chini P, Draganov PV. Kimura et al[ 36 ]. HPB Oxford ; Views Read Edit View history.

The latter approach resulted in a reduced risk of recurrence, even if it maintains still nowadays high morbidity rates. Mural thickening and attenuation pattern of contrast medium may be of help for differentiating normal from pathological papilla[ 65 ].


January 30, First decision: Presentation, treatment and outcome in patients with ampullary tumours. In a small series, photodynamic therapy appeared safe and useful as adjuvant treatment for biliary tract cancer including one case of ampullary carcinoma ampuoma ], but data from larger studies are lacking.

If the subsequent histological exam shows the presence of infiltrating cancer, then the intervention should be converted to PD. Surgical strategy for carcinoma of the papilla of Vater on the basis of lymphatic spread and mode of recurrence.

Several classifications of ampullary carcinomas have been developed according to their gross appearance based on duodenal aspect or extension of neoplasm. Assessment of the nodal status in ampullary carcinoma: As a final consideration, CT is however always necessary for staging any malignant disease, as it can identify distant metastatic involvement like regional lymph-nodes, liver, peritoneum, lung and bone. Patients were divided in 2 subgroups: Median survival was 22 mo range: Adjuvant chemo-radiotherapy in ampullary cancers.

Most ampullary tumors are adenocarcinomas, but are occasionally papillary, adenosquamous or mucinous. Diagnosis of duodenal and ampullary epithelial neoplasms by endoscopic biopsy: Radiation therapy and photodynamic therapy for biliary tract and ampullary carcinomas. Noteably, intestinal differentiation confers a statistically significant survival advantage both in periampullary and in ampullary carcinoma, making the survival rate of ampullary cancer similar to that of duodenal cancer[ 27 ].

A recent study has also shown the importance of tumor budding. Multiple imaging techniques in the diagnosis of ampullary carcinoma.

A common cause of blockage is a gallstone in the common bile duct. Factors predictive of survival in ampullary carcinoma.


Support Radiopaedia and see fewer ads. The strongest predisposition for ampullary neoplastic disease is represented by the familiar adenomatous polyposis FAP syndrome.

Duffy et al[ 92 ]. Compared to sporadic cases, familiar cases of ampullary cancer also tend to present at a younger age. World J Gastrointest Oncol. This study evaluates histopathological features and outcomes of ampullary carcinoma and to compares the survival of these tumors to that of other biliary tract tumors.

Tumors of ampulla of Vater: A case series and review of chemotherapy options

There were patients in the gemcitabine-group ampullary: However, given its limited efficacy, lack of histological data and risk of tumor recurrence, it ampuooma currently regarded only as a palliative procedure[].

Case 5 Case 5. COX-2 expression in ampullary carcinoma: In the series reported by Roggin et al[ ], 7 out of 8 patients treated with ampullectomy experienced recurrence of disease mostly at a loco regional level and had a substantially higher mortality dd with the PD group.

Nerve monitoring and vagal automatic periodic stimulation in robotic thyroid surgery. The median ampulo,a at diagnosis was 64 years range: Fluorouracil vs gemcitabine chemotherapy before and after fluorouracil-based chemoradiation following resection of pancreatic adenocarcinoma: