Management of Benzodiazepine Withdrawal – WS DASSA August Benzodiazepine equivalents. Name. Duration of. Action #. Approx dose. Alprazolam. Xanax. Y**. B. Chlordiazepoxide Librium. Y**. B,E. Clonazepam. Klonopin. – N**. A,B,D,E. Diazepam. Valium. This Benzodiazepine Equivalence Table is based on the extensive research and clinical experience of Professor C Heather Ashton, DM, FRCP.
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Although phenobarbital and secobarbital are not benzodiazepines, they are commonly grouped with this drug class and cited within benzodiazepine conversion charts due to their use in alcohol withdrawal. Indications Benzodiazepine Withdrawal Barbiturate withdrawal Sedative withdrawal. While barbiturates do share similar pharmacology to benzodiazepines, they have a more concerning safety profile with a higher incidence of respiratory depression.
Phenobarbital pharmacokinetics and bioavailability in adults. Unlike opioid equipotent dosingbenzodiazepine equivalence is much less evidence-based and poorly described in the literature. Although access to this website is not restricted, the information found here is intended for use by medical providers.
Br J Clin Pharmacol.
These wide ranges of confidence highlight the lack of firm, evidence-based literature supporting specific conversion ratios. Can J Hosp Pharm. Due to discrepancies in equivvalency literature, many benzodiazepine conversions may have a potential conversion range that is extremely variable eg, by a factor of 10x or greater. Miscellaneous Sedative Equivalents References Extra: Accessed December 31, Given the numerous issues with benzodiazepine equivalence, the importance of reasonable clinical judgment, clinical experience, appropriate patient monitoring, and dose titration are of even greater significance.
The following guiding principles govern the calculator’s logic:. Benzodiazepines Equivalents Alprazolam Xanax Alprazolam 0. The Ashton Manual Online. Updated June 3, This calculator only accounts for differences in bioavailability with midazolam.
Because published benzodiazepine dose conversions are based on oral administration, parenteral formulations may not use the same conversion ratio. Patients should address specific medical concerns with their physicians.
References Ashton Curr Opin Psychiatry Home Academy Blog About. Related links to benzidiazepine sites from Bing. Click here to start from scratch and enter your own patient data.
These images are a random sampling from a Bing search on the term “Benzodiazepine Equivalents. This conversion tool estimates a reasonable equipotent dose between two benzodiazepines.
Page Contents Page Contents How they work and how to withdraw; The Ashton Manual. Bioavailability of diazepam after intravenous, oral and rectal administration in adult epileptic patients. We’ve filled out some of the form to show you this clinical calculator benzodizepine action.
A Comprehensive Study Guide. Back Links pages that link to this page. Absolute bioavailability of oral and intramuscular diazepam: It should be noted, however, that this conversion is based on chronic administration of continuous intravenous lorazepam or midazolam. Most benzodiazepines included in this calculator are only available as oral dosage forms.
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